An elevated systemic immune-inflammation index (SII) is independently associated with increased risks for all-cause and cardiovascular-specific mortality in patients undergoing peritoneal dialysis, according to a study published online Aug. 31 in the Journal of Inflammation Research.
Guanglan Li, from the First Affiliated Hospital at Sun Yat-sen University in Guangzhou, China, and colleagues investigated the relationship between the SII and all-cause and cardiovascular-specific mortality in patients undergoing peritoneal dialysis. The analysis included 1,419 patients receiving peritoneal dialysis (2007 through 2019) with a median follow-up of 42 months.
The researchers found that each one standard deviation increase in the SII was associated with increased all-cause mortality (hazard ratio, 1.202) and cardiovascular-specific mortality (hazard ratio, 1.280) in an adjusted analysis. Compared with low SII, high SII was significantly associated with increased risks for all-cause mortality (hazard ratio, 1.391) and cardiovascular-specific mortality (hazard ratio, 1.637). In subgroup analyses of participants younger than 65 years, results were similar.
“Elevated SII level was independently associated with increased risks of all-cause and cardiovascular disease mortalities in patients undergoing peritoneal dialysis, especially for those younger than 65 years old,” the authors write. “Application of the SII in clinical practice in predicting mortality for patients undergoing peritoneal dialysis requires further multicenter prospective studies.”
Guanglan Li et al, Systemic Immune-Inflammation Index Was Significantly Associated with All-Cause and Cardiovascular-Specific Mortalities in Patients Receiving Peritoneal Dialysis, Journal of Inflammation Research (2023). DOI: 10.2147/JIR.S426961
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